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Tenosynovial giant cell tumor: case report and reviewDavid R Lucas. Arch Pathol Lab Med. 2012 Aug. Free article AbstractTenosynovial giant cell tumors are a group of generally benign intra-articular and soft tissue tumors with common histologic features. They can be roughly divided into localized and diffuse types. Localized types include giant cell tumors of tendon sheath and localized pigmented villonodular synovitis, whereas diffuse types encompass conventional pigmented villonodular synovitis and diffuse-type giant cell tumor. Localized tumors are generally indolent, whereas diffuse tumors are locally aggressive. Recent developments indicate that tenosynovial giant cell tumors are clonal neoplastic tumors driven by overexpression of CSF1. Herein, I report a case of intra-articular, localized tenosynovial giant cell tumor (or localized pigmented villonodular synovitis) and review the classification, histopathology, and recent developments regarding its pathogenesis. Similar articles
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What is giant cell tumor of tendon sheath?Giant cell tumor of tendon sheath (GCTTS) is clinically a slow growing soft tissue mass that develops over a period of months to years. It is the second commonest tumor of the hand [1]. Trauma, inflammation, metabolic disease and a neoplastic etiology are considered as etiological factors [2, 3].
How do you get rid of a giant cell tumor of the tendon sheath?Surgery is the main treatment for tenosynovial giant cell tumors. Your doctor may remove some or all of the tumors, as well as the inflamed joint tissue. You may need another surgery if the tumor returns. The tumors can be removed by open surgery or arthroscopic surgery, which is a less invasive procedure.
Is giant cell tumor malignant or benign?Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer). Giant cell tumors usually occur in young and middle-aged adults. Also called GCT.
What is the most common site for giant cell tumors?A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.
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